Its Monday, April 21 and the Yankees (14-8) are in Cleveland to begin a series against the Guardians (12-9).

Clarke Schmidt is slated to take the mound for New York against Gavin Williams for Cleveland.

The Yankees dominated Tampa Bay over the weekend winning three of four against their AL East rival. Yesterday, Max Fried was again brilliant for the Yankees throwing 7.2 innings of two-hit shutout ball to earn his fourth without a loss. Cody Bellinger supplied the offense with his second home run of the season.

The Guardians swept their weekend series in Pittsburgh. Yesterday they knocked off the Bucs in ten innings on Kyle Manzardo’s sacrifice fly in the extra frame.

Lets dive into tonight’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Yankees at Guardians

  • Date: Monday, April 21, 2025
  • Time: 6:10PM EST
  • Site: Progressive Field
  • City: Cleveland, OH
  • Network/Streaming: YES, CLEG

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Yankees at the Guardians

The latest odds as of Monday:

  • Moneyline: Yankees (-121), Guardians (+101)
  • Spread: Yankees -1.5
  • Total: 8.0 runs

Probable starting pitchers for Yankees at Guardians

  • Pitching matchup for April 21, 2025: Clarke Schmidt vs. Gavin Williams
    • Yankees: Clarke Schmidt (0-0, 4.77 ERA)
      Last outing: 4/16 vs. Kansas City – 5.2IP, 3ER, 4H, 2BB, 2Ks
    • Guardians: Gavin Williams (1-1, 4.58 ERA)
      Last outing: 4/16 at Baltimore – 6.2IP, 5ER, 4H, 4BB, 4Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Yankees at Guardians

  • The Yankees have won 4 straight against AL Central teams
  • The Under is 7-1-2 in Yankees’ games against American League teams this season
  • The Guardians have failed to cover the Run Line in 6 of their last 7 games against the Yankees

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Yankees and the Guardians

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday’s game between the Yankees and the Guardians:

  • Moneyline: NBC Sports Bet is recommending a play on the New York Yankees on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Brad Thomas (@MrBradThomas)



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