Red Sox at Rays prediction: Odds, expert picks, starting pitchers, betting trends, and stats for April 16

Its Wednesday, April 16 and the Red Sox (9-10) are in Tampa to take on the Rays (8-9).

Sean Newcomb is slated to take the mound for Boston against Zack Littell for Tampa Bay.

These teams have split the first two games of the series. Boston won last night, 7-4. Alex Bregman went 5-5 with a couple of home runs to lead the Sox to the win.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Red Sox at Rays

• Date: Wednesday, April 16, 2025
• Time: 7:05PM EST
• Site: George M. Steinbrenner Field
• City: Tampa, FL
• Network/Streaming: NESN, FDSNSUN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Red Sox at the Rays

The latest odds as of Wednesday:

• Moneyline: Red Sox (+121), Rays (-143)
• Spread: Rays -1.5
• Total: 9.0 runs

Probable starting pitchers for Red Sox at Rays

• Pitching matchup for April 16, 2025: Sean Newcomb vs. Zack Littell
  • Red Sox: Sean Newcomb (0-2, 4.97 ERA)
    Last outing: 4/11 at White Sox – 4IP, 6ER, 6H, 2BB, 6Ks
  • Rays: Zack Littell (0-3, 6.88 ERA)
    Last outing: 4/10 vs. Angels – 4IP, 7ER, 8H, 1BB, 4Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Red Sox at Rays

• Tampa Bay is just 6-11 on the Run Line this season
• The Rays’ last 4 games have gone OVER the Total
• Alex Bregman is now hitting .321 for Boston this season
• Rafael Devers is 1 for his last 18 and is sporting a .222 average for the season

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Red Sox and the Rays

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Red Sox and the Rays:

• Moneyline: NBC Sports Bet is recommending a play on the Tampa Bay Rays on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Boston Red Sox at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)