SAN FRANCISCO — The 2026 Major League Baseball regular season begins at Oracle Park on Wednesday night with the San Francisco Giants hosting the New York Yankees.

Left-hander Max Fried (19-5, 2.86 ERA in 2025) takes the mound for the Yankees, while the Giants turn to ace Logan Webb (15-11, 3.22 ERA) in the first game for new manager Tony Vitello. The Giants haven’t reached the postseason or posted a winning record since 2021.

Three-time MVP Aaron Judge leads the way for the Yankees, who begin their campaign looking to snap a 17-year World Series championship drought.

This Opening Day marks the regular-season debut of MLB’s new automated balls and strikes (ABS) system that allows players to challenge balls and strikes.

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Where to watch Giants vs Yankees game time tonight

  • Location: Oracle Park, San Francisco

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See the top 30 highest paid players in MLB baseball

(Salaries in present-day value calculated by MLB Labor Relations Department, impacted by deferrals and signing bonuses)

1. Juan Soto, Mets – $61,875,000

Starting pitcher: LHP Max Fried

Giants starting lineup

Starting pitcher: RHP Logan Webb

This article originally appeared on USA TODAY: Yankees vs Giants MLB Opening Day game time, lineups, live on Netflix

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