The reward for the Cleveland Guardians (88-74) all-time great comeback to overtake the Detroit Tigers (87-75) and claim the American League’s Central Division is…a Wild Card series against those same Tigers.
The Guardians closed the regular season winning 14 of their final 17 games while the Tigers lost 13 of their final 16 games.
Detroit will start probable Cy Young winner Tarik Skubal (13-6, 2.21 ERA). Cleveland has yet to announce who will take the ball in Game 1 but an educated guess points towards Gavin Williams (12-5, 3.06 ERA).
Lets dive into the series and specifically Game 1 and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Tigers at Guardians
- Date: Tuesday, September 30, 2025
- Time: 1:08PM EST
- Site: Progressive Field
- City: Cleveland, OH
- Network/Streaming: ESPN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Tigers at the Guardians
The latest odds as of Monday:
- Moneyline: Detroit Tigers (-169), Cleveland Guardians (+138)
- Spread: Tigers -1.5
- Total: 6.0 runs
Probable starting pitchers for Tigers at Guardians
- Pitching matchup for September 30, 2025:
- Tigers: Tarik Skubal (13-6, 2.21 ERA)
Detroit has lost each of Skubal’s last 3 starts allowing 8 runs over 15.1 innings with 19 strikeouts - Guardians: Gavin Williams (12-5, 3.06 ERA)
Williams has won both of his last 2 starts allowing 2 earned runs over 11 innings with 21 strikeouts
- Tigers: Tarik Skubal (13-6, 2.21 ERA)
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
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Top betting trends & insights to know ahead of Tigers at Guardians
- The Guardians have won 4 of their last 5 home games against AL Central teams
- 4 of the Tigers’ last 5 games against the Guardians have stayed under the Total
- The Guardians have failed to cover the Run Line in their last 4 home games
- Jose Ramirez closed the regular season hitting safely in 10 of 11 games (13-41)
- Riley Greene was 6-39 (.154) over his last 10 games
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for Tuesday’s game between the Tigers and the Guardians
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday’s game between the Tigers and the Guardians:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 6.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
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- Trysta Krick (@Trysta_Krick)
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