The 2026 Men’s NCAA Tournament is down to 16 teams and the injury report remains an important part of sifting through the remaining games in the bracket. Nearly one-third of the teams to qualify for the Sweet 16 are dealing with a significant player hobbled by injury, including No. 1 overall seed Duke.
Several played through the pain to advance through the round of 32, while others are attempting to return from injury as fast as possible with the win-or-go-home element of March Madness looming over their recovery. In most cases, their potential replacement has already been thrust into a bigger role after lingering uncertainty through the first weekend of this year’s tournament.
Here’s a look at the injuries that could most affect the Sweet 16 of the 2026 NCAA Tournament, as well as the potential replacements to watch if these injured stars can’t play when March Madness resumes:
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Most important March Madness injuries (and injury replacements)
Joshua Jefferson, Iowa State (Nate Heise)
The injury status of Iowa State star Joshua Jefferson looms large over the Midwest regional in Chicago, beginning with the Sweet 16 nightcap between the second-seeded Cyclones and No. 6 seed Tennessee on Friday, March 27. The 6-foot-9 NBA prospect suffered a sprained left ankle early in Iowa State’s first-round win over No. 15 seed Tennessee State on March 20 and did not play in its round of 32 victory over No. 7 seed Kentucky two days later.
Sixth man Nate Heise started in place of Jefferson, who is averaging 16.4 points, 7.4 rebounds, and 4.8 assists per game this season for the Cyclones. Heise, a 6-foot-5 guard, responded with 12 points and three assists, but Iowa State got just five points from its bench as a result. Jefferson told reporters he plans to “do everything [in] my power to get healthy” ahead of Friday’s Sweet 16 game.
“Nate has been essentially our sixth starter all year, even when he hasn’t started on the court,” Iowa State coach T.J. Otzelberger said. “I say it over and over again; Nate Heise is someone who’s a fierce competitor, defensively has tremendous pride, getting stops, team defense, getting traffic rebounds, making plays. You can feel that compete every possession. Offensively he steps up and does what’s needed for our team. … Nate is somebody for me that I just have tremendous belief and confidence in, and I know what he can do, and I know what he’ll continue to do.”
C.J. Cox, Purdue (Gicarri Harris)
Purdue sophomore C.J. Cox suffered an apparent knee injury early in the second half of the No. 2 seeded Boilermakers’ win over No. 7 seed Miami in the round of 32 and did not return. Coach Matt Painter told reporters after the game that Cox had “hyperextended” his knee and would see how it responded to treatment this week.
Cox called it “nothing serious” and said he could have re-entered the game if needed. The 6-3 guard had three 3-pointers that helped Purdue erase a first-half deficit against Miami before leaving the game due to injury. He has started every game for the Boilermakers this season, while averaging 8.5 points, 2.6 rebounds and 1.3 assists.
If Cox can’t play, or is limited, when Purdue faces No. 11 seed Texas Thursday, March 26 in the Sweet 16, Gicarri Harris is likely to take on a bigger role. He replaced Cox against the Hurricanes and buried his only 3-pointer within three minutes of entering the game. Harris also had two steals as the primary defender on Miami guard Tre Donaldson down the stretch.
Silas Demary Jr., UConn (Malachi Smith)
UConn’s point guard was initially listed as questionable by the Huskies in their NCAA player availability report before coming off the bench in the No. 2 seed’s round of 32 win over No. 7 seed UCLA. Though he had just two points, Demary finished with four assists and two steals after missing the Huskies’ first-round win over No. 15 seed Furman. He initially suffered an ankle injury in the second half of UConn’s Big East Tournament final loss to St. John’s on March 14.
Graduate transfer Malachi Smith, who came to UConn from Dayton ahead of this season having never played in an NCAA Tournament game before, has produced 13 assists starting in place of Demary the past two games. Smith’s minutes have increased substantially with Demary hobbled, setting new season highs for playing time at UConn in its two March Madness games thus far.
Coach Dan Hurley told reporters after Smith’s first-round performance that the team thought Smith had also hurt his knee in a practice collision before leaving for the NCAA Tournament. “He was banged up out there playing 31 minutes. The guy’s a warrior and showed that New York toughness today.”
Caleb Foster, Duke (Cayden Boozer)
Duke starting point guard Caleb Foster hasn’t played for the Blue Devils since suffering a broken foot in the team’s regular-season finale against North Carolina March 6. But coach Jon Scheyer left the door open for him to return in time for No. 1 seed Duke’s Sweet 16 matchup against No. 5 seed St. John’s on Friday, March 27.
“Not to reference ‘Dumb and Dumber,’ but when he first got hurt, I felt like maybe it was one in a million,” Scheyer told CBS Sports’ Jon Rothstein on Monday. “Since then, the way Caleb has worked, the chances have continued to increase. I think there’s an outside chance, maybe for Friday.
“He’s trying to do the impossible here and try to come back as soon as he can,” Scheyer added. “This weekend, I don’t think I can rule it out because of who he is and how he’s been working.”
Cayden Boozer has moved into the starting lineup for Foster and performed well during the ACC Tournament and the first two games of Duke’s NCAA Tournament run. He had a career-high 19 points and five assists when the Blue Devils came back in the second half to beat No. 16 seed Siena in the first round.
Nate Ament, Tennessee (Jaylen Carey or Amari Evans)
Ament, a potential NBA lottery pick, is playing through ankle and knee injuries that forced him to miss two games at the end of Tennessee’s regular-season schedule. He was used for just 18 minutes in the Vols’ opening round NCAA win over Miami (Ohio) and then gutted through a 16-point, 4-rebound performance against Virginia in the round of 32. He’s shooting 5-for-27 from the field over the past three games.
“For me, I wanted to do it for my teammates and this university. I owe them so much,” Ament said after the game. “The least I could do is fight through this.”
Jaylen Carey started six consecutive games when Ament didn’t play to close the regular season, but the Vols have altered their lineups since then. J.P. Estrella was moved back into a starting role beginning with the SEC Tournament, with Amari Evans shifted to the bench along with Carey. Tennessee Coach Rick Barnes can turn to the 6-foot-5 Evans for more versatility or the 6-foot-8 Carey for more size inside if Ament can’t go or significantly limited by injury.
This article originally appeared on USA TODAY: March Madness 2026 injury update for NCAA Tournament Sweet 16 games
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