Padres at Blue Jays prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 22

Its Thursday, May 22 and the Padres (27-20) are in Toronto to take on the Blue Jays (24-24).

Stephen Kolek is slated to take the mound for San Diego against Bowden Francis for Toronto.

The Jays have blanked the Padres each of the last two days. Yesterday, Toronto smacked San Diego 14-0. Daulton Varsho cleared the bases with a grand slam and the Blue Jays collected 14 hits in the beating.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Padres at Blue Jays

• Date: Thursday, May 22, 2025
• Time: 1:07PM EST
• Site: Rogers Centre
• City: Toronto, ON
• Network/Streaming: SDPA, Sportsnet, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Padres at the Blue Jays

The latest odds as of Thursday:

• Moneyline: Padres (-114), Blue Jays (-106)
• Spread: Padres -1.5
• Total: 9.0 runs

Probable starting pitchers for Padres at Blue Jays

• Pitching matchup for May 22, 2025: Stephen Kolek vs. Bowden Francis
  • Padres: Stephen Kolek (2-1, 2.33 ERA)
    Last outing: 5/16 vs. Seattle – 5IP, 5ER, 8H, 1BB, 4Ks
  • Blue Jays: Bowden Francis (2-6, 5.63 ERA)
    Last outing: 5/16 vs. Detroit – 4.2IP, 4ER, 8H, 2BB, 6Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Padres at Blue Jays

• The Jays have outscored the Padres 17-0 through two games of the series
• The Under is 26-20-1 in Padres’ games this season
• The Blue Jays are up 2.14 units on the Run Line in their last 5 games at Rogers Centre
• George Springer collected 2 hits last night to snap an 0-15 streak

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for today’s game between the Padres and the Blue Jays

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday’s game between the Padres and the Blue Jays:

• Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Toronto Blue Jays at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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• Jay Croucher (@croucherJD)
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• Brad Thomas (@MrBradThomas)