The Tennessee Titans and Indianapolis Colts will meet at Nissan Stadium in Week 6 for what is the first of two matchups between the AFC South rivals.

The Titans finally notched their first win of the 2024 campaign in Week 4, beating the Tua Tagovailoa-less Miami Dolphins, 31-12, before going into their bye week. The 30-point showing was Tennessee’s first in over 1,000 days, which is almost unfathomable.

On the other sideline will be the Colts, who are coming off a Week 5 loss to the Jacksonville Jaguars, which snapped Indy’s two-game winning streak. The ageless Joe Flacco still had yet another impressive outing, though.

Despite Flacco’s success, the Colts plan on going back to second-year signal-caller Anthony Richardson once healthy, but his status remains up in the air after logging a limited practice once again to start the week.

Without further ado, here’s what experts are saying and predicting for the Week 6 contest between Tennessee and Indianapolis.

NFL picks, predictions Week 6: Colts vs. Titans

Vinnie Iyer, Sporting News: Colts 20, Titans 17

Iyer: “Will Anthony Richardson (oblique) and Jonathan Taylor (ankle) return at the same for the Colts after missing one game? Joe Flacco was an OK pass-happy fill-in, so that makes Taylor a little more important after not being able to close well in Jacksonville. The Titans will have a few more offensive answers under Brian Callahan by continuing to lean more on running backs Tony Pollard and Tyjae Spears, but either Will Levis or Mason Rudolph will make one too many mistakes in relation to Flacco or Richardson.”

Bill Bender, Sporting News: Colts 30, Titans 27

Bender: “The Colts are 2-3, and their five games have been decided by a combined total of 19 points. They have been a hard team to gauge as a result. Joe Flacco averages 263.5 passing yards per game with five TDs and no interceptions. Will Indianapolis ride this out even if Anthony Richardson (oblique) is close to returning? The Titans are coming out of the bye week after a rough start that includes a minus-7 turnover ratio through four games. Indianapolis is 4-1 ATS this season.”

Pete Prisco, CBS Sports: Titans 27, Colts 20

Prisco: “The Colts are coming off a loss at Jacksonville, so they are out on the road two straight weeks. The Titans are off a bye. Big edge to the home team. The health of both quarterbacks bears watching, but no matter who plays quarterback for either team the big edge goes to the Titans defense. The Colts can’t stop anybody. Titans win it.”

ESPN

Mike Clay: Colts

Dan Graziano: Titans

Kalyn Kahler: Colts

Kimberley A. Martin: Colts

Eric Moody: Colts

Jason Reid: Colts

Lindsey Thiry: Titans

Seth Wickersham: Titans

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