It’s Wednesday, June 25 and the Cubs (46-33) are in St. Louis to take on the Cardinals (44-36). Matthew Boyd is slated to take the mound for Chicago against Erick Fedde for St. Louis.
With an 8-7 win yesterday, the Cardinals have won the first two games of the series. Masyn Winn had a big game for the Cardinals. He was one of three Cardinals to homer in last night’s game.
Let’s dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Cubs at Cardinals
- Date: Wednesday, June 25, 2025
- Time: 7:45PM EST
- Site: Busch Stadium
- City: St. Louis, MO
- Network/Streaming: FanDuel Sports Network Midwest, Marquee Sports Network
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cubs at the Cardinals
The latest odds as of Wednesday:
- Moneyline: Cubs (-130), Cardinals (+109)
- Spread: Cubs -1.5
- Total: 9.0 runs
Probable starting pitchers for Cubs at Cardinals
- Pitching matchup for June 25, 2025: Matthew Boyd vs. Erick Fedde
- Cubs: Matthew Boyd, (6-3, 2.84 ERA)
Last outing (Seattle Mariners, 6/20): 5.0 Innings Pitched, 2 Earned Runs Allowed, 2 Hits Allowed, 2 Walks, and 6 Strikeouts - Cardinals: Erick Fedde, (3-6, 3.54 ERA)
Last outing (Chicago White Sox, 6/19): 5.0 Innings Pitched, 1 Earned Runs Allowed, 6 Hits Allowed, 2 Walks, and 4 Strikeouts
- Cubs: Matthew Boyd, (6-3, 2.84 ERA)
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Top betting trends & insights to know ahead of Cubs at Cardinals
- The Cardinals have won 4 of their last 5 games at home, while the Cubs have lost on 3 straight road trips
- Each of the Cubs’ last 5 games at the Cardinals have gone over the Total
- The Cubs have failed to cover the Run Line in 10 of their last 12 games
If you’re looking for more key trends and stats around the spread, moneyline, and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Cubs and the Cardinals
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread, and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information, and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Cubs and the Cardinals:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
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- Vaughn Dalzell (@VmoneySports)
- Brad Thomas (@MrBradThomas)
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