Its Tuesday, July 22 and the Astros (58-42) are in Phoenix to take on the Diamondbacks (50-51).
Framber Valdez is slated to take the mound for Houston against Eduardo Rodriguez for Arizona.
The American League West leaders took the series opener last night, 6-3. Rookie Brice Matthews cracked the first two home runs of his career and drove in five of the six runs for the Astros. Colton Gordon started for Houston lasting 5.2 innings and allowing three runs (two earned) to earn his fourth win of the season. Top trade target Eugenio Suarez homered for the fifth time in the last three games for Arizona in the loss.
Lets dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Astros at Diamondbacks
- Date: Tuesday, July 22, 2025
- Time: 9:40PM EST
- Site: Chase Field
- City: Phoenix, AZ
- Network/Streaming: SCHN, ARID
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Astros at the Diamondbacks
The latest odds as of Tuesday:
- Moneyline: Astros (-125), Diamondbacks (+105)
- Spread: Astros -1.5
- Total: 8.0 runs
Probable starting pitchers for Astros at Diamondbacks
- Pitching matchup for July 22, 2025: Framber Valdez vs. Eduardo Rodriguez
- Astros: Framber Valdez (10-4, 2.75 ERA)
Last outing: July 12 vs. Texas – 6IP, 0ER, 4H, 0BB, 10Ks - Diamondbacks: Eduardo Rodriguez (3-6, 5.94 ERA)
Last outing: July 10 at San Diego – 4IP, 4ER, 8H, 2HR, 2BB
- Astros: Framber Valdez (10-4, 2.75 ERA)
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Top betting trends & insights to know ahead of Astros at Diamondbacks
- The Diamondbacks had their 4-game win streak snapped last night
- The Astros have covered in 4 of their last 5 road games and bettors who have bet accordingly are profiting 1.49 units
- Eugenio Suarez has hit in 4 straight (6-14) with 5 HRs and in 6 of his last 7 (9-21) with 7 HRs
- Brice Matthews is 3-9 over his last 3 games
- Jose Altuve is 23-63 (.365) in July
- Christian Walker is 5-12 (.417) over his last 3 games and is hitting .339 in July overall
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Astros and the Diamondbacks
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday’s game between the Astros and the Diamondbacks:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Arizona Diamondbacks at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
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- Brad Thomas (@MrBradThomas)
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