White Sox at Reds Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 15

Its Thursday, May 15 and the White Sox (14-29) are in Cincinnati to take on the Reds (20-24).

Bryse Wilson is slated to take the mound for Chicago against Nick Martinez for Cincinnati.

Last night the White Sox achieved a season-first: they won a third consecutive game with a 4-2 win over the Reds. Davis Martin and four relievers combined to limit the Reds to single runs in the seventh and eighth innings.

Lets dive into this afternoon’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch White Sox at Reds

• Date: Thursday, May 15, 2025
• Time: 12:40PM EST
• Site: Great American Ball Park
• City: Cincinnati, OH
• Network/Streaming: CHSN, FDSNOH, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the White Sox at the Reds

The latest odds as of Thursday:

• Moneyline: White Sox (+182), Reds (-221)
• Spread: Reds -1.5
• Total: 9.0 runs

Probable starting pitchers for White Sox at Reds

• Pitching matchup for May 15, 2025: Bryse Wilson vs. Nick Martinez
  • White Sox: Bryse Wilson (0-1, 4.88 ERA)
    Last outing: 5/9 vs. Miami – 5IP, 1ER, 3H, 2BB, 1K
  • Reds: Nick Martinez (1-4, 4.23 ERA)
    Last outing: 5/9 at Houston – 6IP, 3ER, 10H, 0BB, 5Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of White Sox at Reds

• The White Sox have lost 9 of 14 games this season following a win
• The Under is 4-1 in the Reds’ last 5 games
• The White Sox have covered in 4 of their last 5 games for a profit of 2.21 units
• Lenyn Sosa has picked up two hits in 4 of the last 5 games (8-18)
• Elly De La Cruz is 4-25 (.160) over his last 6 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for today’s game between the White Sox and the Reds

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday’s game between the White Sox and the Reds:

• Moneyline: NBC Sports Bet is recommending a play on the Cincinnati Reds on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago White Sox at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)