The NFL is set to drop the full 2025 regular season schedule tonight, giving Cardinals fans their first look at how Arizona’s season will stack up week by week — including when the toughest matchups will hit and whether the national spotlight will follow.
After a rebuilding 2024 campaign that saw flashes of promise under quarterback Kyler Murray, Arizona enters the new season with renewed expectations and a roster full of young talent. The opponents have been locked in since the end of last year, but now it’s about timing — and how the Cardinals navigate one of the more difficult schedules in the league.
Arizona Cardinals’ 2025 opponents
Home games: Los Angeles Rams, San Francisco 49ers, Seattle Seahawks, Atlanta Falcons, Carolina Panthers, Jacksonville Jaguars, Tennessee Titans, Green Bay Packers
Road games: Rams, 49ers, Seahawks, Houston Texans, Indianapolis Colts, Tampa Bay Buccaneers, New Orleans Saints, Dallas Cowboys, Cincinnati Bengals
Arizona Cardinals 2025 full schedule
Here’s a look at the Cardinals’ full 2025 schedule. Remember, any game listed as a rumor is based on unofficial leaks and could still change before the NFL announces the complete schedule at 8 p.m. ET on Wednesday, May 15.
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Week 1 – at New Orleans Saints (rumor)
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Week 2 – vs. Carolina Panthers (rumor)
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Week 3 – at San Francisco 49ers (rumor)
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Week 4 –
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Week 5 –
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Week 6 – at Indianapolis Colts (rumor)
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Week 7 –
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Week 8 –
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Week 9 – at Dallas Cowboys – Monday Night Football (rumor)
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Week 10 –
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Week 11 –
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Week 12 –
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Week 13 –
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Week 14 –
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Week 15 –
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Week 16 –
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Week 17 –
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Week 18 –
Cardinals 2025 strength of schedule
According to Sharp Football Analysis, the Cardinals face the 11th-toughest schedule in the NFL based on projected win totals — the hardest slate among any team in the NFC West. With road games against contenders like the Bengals, Cowboys, and 49ers, Arizona will be tested early and often.
Cardinals schedule release date and time
When: Wednesday, May 15, 8 p.m. ET
Watch: NFL Network, ESPN
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