Its Thursday, August 21 and the Astros (69-58) are in Baltimore to take on the Orioles (59-67). Jason Alexander is slated to take the mound for Houston against Brandon Young for Baltimore.
Baltimore and Houston just met August 15-17 and the Orioles won two out of three against the Astros. Baltimore met Boston since then and won both games, while Houston dropped three consecutive games to Detroit. The Astros have lost four straight games, while the Orioles have won the past three.
Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Astros at Orioles
- Date: Thursday, August 21, 2025
- Time: 7:15PM EST
- Site: Oriole Park at Camden Yards
- City: Baltimore, MD
- Network/Streaming: FOX
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Astros at the Orioles
The latest odds as of Thursday:
- Moneyline: Astros (-109), Orioles (-110)
- Spread: Orioles 1.5
- Total: 9.0 runs
Probable starting pitchers for Astros at Orioles
- Pitching matchup for August 21, 2025: Jason Alexander vs. Brandon Young
- Astros: Jason Alexander, (3-1, 18.00 ERA)
Last outing: 3.00 ERA, 2 Earned Runs Allowed, 3 Hits Allowed, 0 Walks, and 6 Strikeouts - Orioles: Brandon Young, (1-6, 5.68 ERA)
Last outing: 0.00 ERA, 0 Earned Runs Allowed, 1 Hits Allowed, 0 Walks, and 6 Strikeouts
- Astros: Jason Alexander, (3-1, 18.00 ERA)
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Expert picks & predictions for tonight’s game between the Astros and the Orioles
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Thursday’s game between the Astros and the Orioles:
- Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Houston Astros at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 9.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Astros at Orioles
- Baltimore is 2-1 versus Houston this season
- Houston is 0-4 in the last 4 games
- Houston is 2-6 in the last 8 games
- Baltimore is 3-0 in the last 3 games
- Baltimore is 6-1 in the last 7 games
- The Astros have won 4 of their last 5 away games against teams with losing records
- The Under has cashed in 10 of the Orioles’ last 12 games with a rest advantage over their opponents
- The Astros have failed to cover in their last 3 games against the Orioles
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
- Drew Dinsick (@whale_capper)
- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)
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